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These genes share a common biochemical pathway that leads to abnormal production of amyloid beta (a protein that accumulates in the brain of Alzheimer’s patients). https://www.associatesinneurology.com/frequently-asked-questions-what-are-the-risk-factors-for-alzheimers-disease/. ApoE, which plays an important role in cholesterol transport in the body, is a genetic factor that may influence amyloid toxicity and the age of onset of symptoms related to Alzheimer’s.

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